Receptor tyrosine kinase (RTK) is one of the six consortes of enzyme-linked sensory receptorshave thus faraway been identified. Receptor tyrosine kinases have high affinity cell surfacereceptors for more polypeptide growth factors, cytokines and hormones. They argon thekey regulators of normal cellular processes and also turn of events a critical role in thedevelopment and progression of many another(prenominal) types of cancer. In addition, theyphosphorylate specific tyrosines on a small preen of intracellular signaling proteins.
The Structure of RTK
Most of the receptor tyrosine kinases are single subunit receptors but some exist asmultimeric complexes such as insulin receptor. Each monomer has a singletransmembrane spanning domain composed of 25-38 aminic acids, an extracellular N-terminal region and an intracellular C-terminal region. The N-terminal region consistsof a pear-shaped protein domain which binds to a particular growth factor or hormone whilethe C-terminal region comprises domains in charge for the kinase activity of the receptors.
in that respect are many cell-surface-bound signal proteins bind to these receptors.Approximately more than 16 different circlees of receptor tyrosine kinases have beenidentified, each dedicated to its completing family of protein ligands. Below arethe examples of subfamilies:
1.
RTK class I (Epidermal increase compute (EGF) receptor family)
2.RTK class II (Insulin receptor family)
3.RTK class III (Platelet-derived Growth factor (PDGF) receptor family)
4.RTK class IV (Fibroblast Growth factor in (FGF) receptor family)
5.RTK class V (Vascular Endothelial Growth Factor (VEGF) receptors family)
6.RTK class VI (Hepatocyte Growth Factor (HGF) receptor family)
7.RTK class VII (Tropomyosin-receptor-kinase (Trk) receptor family)
8.RTK class XI (Angiopoeitin (TIE) receptor family)
9.RTK class XVII (Muscle Specific Kinase (MuSK) receptor family)
Activated Receptor Tyrosine Kinases Phosphorylate Themselves
The ski binding of a signal protein to the receptor outside...If you want to get a full essay, order it on our website: Ordercustompaper.com
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