Regulating the Tumor Suppressor Gene Maspin in Breast Cancer Cells

TAM was confirmed as the bewilderr by Western blot analysis from swear and TAM-treated MCF-7 and HMEC133 cubicles. The data from this study, although carried out on a small be of patients, suggests that current treatment with Tamoxifen is at doses too clinical depression to fully eradicate tumor recurrence, so a larger study is needed to provided statistically significant data with which to work.

Cao, W> M., Murao, K., Imachi, H., Yu, X., Abe, H., Yamauchi, A., Niimi, M., Miyauchi, A., Wong, N. C. W., & Ishida, T. (2004). A mutant high-density lipoprotein receptor inhibits proliferation of human knocker crabby person cells. crab louse Research, 64, 1515-1521.

In this study, Cao et al (2004) looked at the role of high-density lipoprotein (HDL) in cell proliferation and apoptosis in human mammilla cancer cells. They created a mutant of CLA-1, mCLA, which lacked the -COOH-terminal tail; CLA-1 is known

to collaborate with HDL. The study showed that expression of mCLA prevented the proliferation of human breast cancer cell line MCF-7, but the inhibitory action necessary the presence of the transcriptional factor activator protein-1 (AP-1) for its inhibitory action.

The mutant receptor modify the antiapoptotic properties of HDL at the same time.

Manna, P. P., & Frazier, W. A. (2004). CD47 mediates killing of breast tumor cells via Gi-dependent inhibiting of protein kinase A. Cancer Research, 64, 1026-1036.

Manna and Frazier (2004) studied the thrombospondin (TSP) responder CD47 (integrin-associated protein) which has been reported to induce a novel form of apoptosis. They looked at the response of breast cancer cells to the CD47 ligands TSP-1; the peptide 4NIK-1, which is a TSP-1-derived agonist of CD47; and an anti-CD47 monoclonal antibody, 1F7, and found that CD47-mediated breast cancer cell death did not need progressive caspases or
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